Tizanidine 6mg as hydrochloride

Silicon dioxide colloidal, Stearic acid, microcrystalline cellulose lactose monohydrate, and anhydrous lactose.

- F.C. Scored S.R. tablets containing Tizanidine hydrochloride.

Tizanidine is centrally acting as muscle relaxant /anti spasticity agent. Its principal site of action is the spinal cord.

Tizanidine is effective in both acute painful muscle spasms and chronic spasticity of spinal and cerebral origin.it reduces resistance to passive movement, alleviates spasms and clonus, and improves voluntary strength. sustained release of the active ingredient from Tizanidine S.R. tablets means that high initial peaks are avoided, and therapeutic plasma concentrations maintained over 24 hours.

Sustained release of Tizanidine from S.R. tablet results in a smoother pharmacokinetics profile by avoiding high initial peaks in the plasm. Under steady state conditions, peak plasma concentrations are attained within approx..6 hours. They correspond to are approx..40% of the peak plasma concentration attained after the same daily doses of tizanidine in tablet form are given in three divided doses. Therapeutic plasma levels are maintained 24 hours.

-Painful muscles spasm.

-Spasticity due to multiple sclerosis.

-Spasticity due to spinal cord injury.

-Spasticity due to brain injury.

Adults: Relief of painful muscle spasms :3mg three times daily in tablet form.in sever cases an additional dose of 3mg may be taken at bedtime.

Spasticity due to neurological disorders: the dosage should be adjusted to the needs of the individual patients, the recommended starting dose is one 6mg S.R. Tablet once daily, if necessary, it may be increased stepwise by one 6mg S.R. tablet at half -weekly or weekly intervals, the standard dose is 6-24 mg once daily, clinical experience has shown the optimum dose in most patients to be 12mg once daily ,24mg only being required in a rare case.one 12mg tablet may be given instead of two 6mg tablets.

Adverse effects-such as drowsiness, fatigue, light head, dry mouth, reduced blood pressure, nausea, gastrointestinal disorders and elevated serum transaminases are usually mild and transient in patients using low doses, such as those recommended for treatment of painful muscle spasms., with higher doses such as those recommended for treatment of spasticity, the above-mentioned reaction are more pronounced, but seldom severe enough to require discontinuation of treatment. The following adverse effects may also occur hypotension, bradycardia, muscle weakness, insomnia, sleep disorders, hallucinations, and hepatitis.

Concomitant administration of tizanidine with fluvoxamine and ciprofloxacin which are both potent CYP1A2 inhibitor in man.is contraindicated (see contraindications).concomitant administration of tizanidine with fluvoxamine results in a 33-fold increase in AUC of tizanidine while concomitant administration of tizanidine with ciprofloxacin results in 10- fold increase in AUC of tizanidine ,this may lead to clinical significant and prolonged drop in blood pressure ,accompanied by drowsiness, light head and decrease psychomotor performance (see contraindications).concomitant administration of other  CYP1A2 inhibitors such as arrhythmic (amiodarone, mexiletine, propafenone),cimetidine ,some fluroquinolones ,rofecoxib. oral contraceptive and ticlopidine not recommended, concomitant use of tizanidine with antihypertensives agent including diuretics can occasionally cause hypotension and bradycardia, tizanidine may potentiate the effects of alcohol and sedatives.

Patients experiencing drowsiness or dizziness should refrain from activities requiring a high degree of alertness (e.g., driving, using machines).

-A carton box of 2or 3 (ALU/PVC) strips each of 10 F.C. scored S.R. tablets

-keep at room temperature

-keep out of children.

Follow strictly your physician prescription-tablet should be swallowed with some water.

-do not interrupt the treatment from yourself or repeat it.

-you can take Caredaloud S.R. tablet with or without food.

Shelf-life: Do not use after the expiry date (=EXP.) printed on the pack.